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KMID : 0624620160490070376
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BMB Reports
2016 Volume.49 No. 7 p.376 ~ p.381
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c-Jun N-terminal Kinase (JNK) induces phosphorylation of amyloid precursor protein (APP) at Thr668, in okadaic acid-induced neurodegeneration
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Ahn Ji-Hwan
So Sang-Pil
Kim Na-Young
Kim Hyun-Ju
Yoon Seung-Yong
Kim Dong-Hou
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Abstract
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Several lines of evidence have revealed that phosphorylation of amyloid precursor protein (APP) at Thr668 is involved in the pathogenesis of Alzheimer’s disease (AD). Okadaic acid (OA), a protein phosphatase-2A inhibitor, has been used in AD research models to increase tau phosphorylation and induce neuronal death. We previously showed that OA increased levels of APP and induced accumulation of APP in axonal swellings. In this study, we found that in OA-treated neurons, phosphorylation of APP at Thr668 increased and accumulated in axonal swellings by c-jun N-terminal kinase (JNK), and not by Cdk5 or ERK/MAPK. These results suggest that JNK may be one of therapeutic targets for the treatment of AD.
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KEYWORD
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Alzheimer’s disease, APP, JNK, Okadaic acid, PP2A
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